Anzemet (Dolasetron Mesylate)

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Dolasetron Mesylate Information

Dolasetron Injection (dol a' se tron) Anzemet® Injection

Dolasetron injection is used to prevent and treat nausea and vomiting that may occur after surgery. Dolasetron injection should not be used to prevent or treat nausea and vomiting in people receiving cancer chemotherapy medications. Dolasetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Dolasetron injection comes as a solution (liquid) to be injected intravenously (into a vein) by a healthcare provider in a hospital or clinic. It is usually given as a single injection just before the end of surgery or as soon as nausea or vomiting occurs. Dolasetron injection may be mixed in apple or apple-grape juice for children to take by mouth. It usually is given within 2 hours before surgery. This mixture may be kept at room temperature but must be used within 2 hours after mixing.

Before using dolasetron injection, tell your doctor and pharmacist if you are allergic to dolasetron, any other medications, or any of the ingredients in dolasetron injection. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cimetidine; diuretics ('water pills'); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys); lithium (Lithobid); medications to control blood pressure; medications for irregular heart beat such as atenolol (Tenormin, in Tenoretic); flecainide , quinidine (in Nuedexta), and verapamil (Calan, Covera-HS, Verelan, in Tarka); medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you or anyone in your family has or has ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), or another type of irregular heart beat or heart rhythm problem, or if you have or have ever had low levels of potassium or magnesium in your blood, heart failure, or kidney disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Unless your doctor tells you otherwise, continue your normal diet.

Dolasetron injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache drowsiness chills Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or seek emergency medical treatment: hives rash itching difficulty breathing or swallowing changes in heart beat or heart rhythm dizziness lightheadedness, or fainting fast, slow or irregular heartbeat agitation confusion nausea, vomiting, or diarrhea loss of coordination stiff or twitching muscles seizures coma (loss of consciousness) Dolasetron injection may cause other side effects. Call your doctor if you have any unusual problems while using this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light and excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Keep all appointments with your doctor. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.