Before taking mifepristone,
tell your doctor if you are allergic to mifepristone, any other medications, or any of the ingredients in mifepristone tablets. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
tell your doctor if you are taking any of the following medications or have taken them in the last two weeks: corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, others), fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, others), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf); dihydroergotamine (D.H.E. 45, Migranal); ergotamine (Ergomar, in Cafergot, in Migergot); fentanyl (Duragesic); lovastatin (Mevacor); pimozide (Orap); quinidine (Quinidex); and simvastatin (Zocor). Your doctor will probably tell you not to take mifepristone if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or have taken in the last two weeks. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antifungals such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); bupropion (Wellbutrin); ciprofloxacin (Cipro); clarithromycin (Biaxin); conivaptan (Vaprisol); diltiazem (Cardizem); erythromycin (E.E.S., E-Mycin, Erythrocin); fluvastatin (Lescol); hormonal contraceptives such as birth control pills, implants, patches, rings, or injections; medications for hepatitis C such as boceprevir (Victrelis) and telaprevir (Incivek); medications for HIV or AIDS such as amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir and ritonavir combination (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); medications for tuberculosis such as rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater) and rifapentine (Priftin); nefazodone (Serzone); repaglinide (Prandin); telithromycin (Ketek); and verapamil (Calan, Isoptin, others). Many other medications may also interact with mifepristone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor what herbal products you are taking, especially St. John's Wort.
tell your doctor if you have ever had an organ transplant or if you have or ever had thyroid disease. If you are a woman and have not had surgery to remove your uterus, tell your doctor if you have or have ever had unexplained vaginal bleeding, endometrial hyperplasia (overgrowth of the lining of the uterus), or endometrial cancer (cancer of the lining of your uterus). Your doctor will probably tell you not to take mifepristone.
tell your doctor if you have or have ever had heart failure, a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), low potassium in your blood, adrenal insufficiency(condition in which the adrenal glands do not produce enough of certain hormones needed for important body functions), a bleeding disorder, or liver, kidney, or heart disease.
tell your doctor if you are breast-feeding.